The crystal and molecular structure of the tricyclic antidepressant chlorimipramine hydrochloride

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TypeArticle
Journal titleActa Crystallographica
VolumeB33
Pages25902595; # of pages: 6
AbstractThe structure of chlorimipramine hydrochloride was determined by the symbolic addition procedure and refined by block-diagonal least-squares to an R of 0.048 for 2569 diffractometer-measured reflexions. The dihedral angle between the aromatic-ring mean planes is 123 degrees and the tricyclic moiety has twist and skew values of 17.6 degrees and 0.66 A respectively. The dimethylaminopropyl side chain exhibits a grouche-trans rotamer which is unusual, in the solid state, for compounds of this type. Conformational parameters for the seven-membered hetero-ring in the title compound, and related tricycles, are discussed.
Publication date
LanguageEnglish
AffiliationNRC Institute for Chemical Process and Environmental Technology; National Research Council Canada
Peer reviewedYes
NRC number15976
NPARC number5753376
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Record identifier2b575e51-a099-47a7-bb93-1069dd84b6cc
Record created2008-12-02
Record modified2016-05-09
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