Probing inhibitory effects of nanocrystalline cellulose: inhibition versus surface charge

Alternative titleProbing inhibitory effects of nanocrystalline cellulose using insect cell-based impedance spectroscopy
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DOIResolve DOI: http://doi.org/10.1039/c2nr11886f
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TypeArticle
Journal titleNanoscale
ISSN2040-3364
2040-3372
Volume4
Issue4
Pages13731379; # of pages: 7
AbstractNCC derived from different biomass sources was probed for its plausible cytotoxicity by electric cell-substrate impedance sensing (ECIS). Two different cell lines, Spodoptera frugiperda Sƒ9 insect cells and Chinese hamster lung fibroblast V79, were exposed to NCC and their spreading and viability were monitored and quantified by ECIS. Based on the 50%-inhibition concentration (ECIS₅₀), none of the NCC produced was judged to have any significant cytotoxicity on these two cell lines. However, NCC derived from flax exhibited the most pronounced inhibition on Sƒ9 compared to hemp and celluslose powder. NCCs from flax and hemp pre-treated with pectate lyase were also less inhibitory than NCCs prepared from untreated flax and hemp. Results also suggested a correlation between the inhibitory effect and the carboxylic acid contents on the NCC.
Publication date
PublisherRSC Publishing
LanguageEnglish
AffiliationNational Research Council Canada; NRC Biotechnology Research Institute
Peer reviewedYes
NRC number55427
NPARC number21268413
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Record identifier2b7c087c-cb59-42f3-98c0-99a169cf5887
Record created2013-07-10
Record modified2016-05-09
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