Triflusal reduces cerebral ischemia induced inflammation in a combined mouse model of Alzheimer's disease and stroke

Download
  1. Get@NRC: Triflusal reduces cerebral ischemia induced inflammation in a combined mouse model of Alzheimer's disease and stroke (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1016/j.brainres.2010.10.008
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleBrain Research
Volume1366
Pages246256; # of pages: 11
AbstractClinical data has shown that stroke exacerbates dementia in Alzheimer's disease (AD) patients. Previous work, combining ratmodels ofADand stroke have shown that neuroinflammationmay be the common mediator between AD and stroke toxicity. This study examined the effects of triflusal (2-acetoxy-4-trifluoromethylbenzoic acid) in APP23 transgenicmice receiving strokes. Six month-old APP23 mice over-expressing mutant human amyloid precursor protein (APP) were used to model AD in this study. Unilateral injections of a potent vasoconstrictor, endothelin-1, into the striatumwere used tomimic small lacunar infarcts. Immunohistochemical analysis was performed to examine AD-like pathology and inflammatory correlates of stroke and AD. APP23 mice showed increases in AD-like pathology and inflammatorymarkers of AD in the cortex and hippocampus. Endothelin-induced ischemia triggered an inflammatory response along with increases in AD pathologicalmarkers in the region of the infarct. Triflusal reduced inflammation surrounding the endothelin-induced infarct only.At thedoseused,anti-inflammatory treatment may be beneficial in reducing the AD and inflammatory correlates of stroke in a combined ADstroke mouse model.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NPARC number17652984
Export citationExport as RIS
Report a correctionReport a correction
Record identifier2b90de1c-9721-4a6a-a161-79c88ff5c095
Record created2011-04-01
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)