Bioactive components of the edible strain of red alga, Chondrus crispus, enhance oxidative stress tolerance in Caenorhabditis elegans

Alternative titleCultivated seaweeds as functional food: Bioactive organic extract of the red alga, Chondrus crispus, increases stress tolerance in the model worm Caenorhabditis elegans
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DOIResolve DOI: http://doi.org/10.1016/j.jff.2013.04.001
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TypeArticle
Journal titleJournal of Functional Foods
ISSN17564646
Volume5
Issue3
Pages11801190; # of pages: 11
SubjectCaenorhabditis elegans; Chondrus crispus; Cultivated seaweeds; Functional foods; Stress tolerance
AbstractSeaweeds are rich sources of bioactive compounds with potential health benefits. Anti-stress effects of the cultivated red alga, Chondrus crispus, were investigated in the Caenorhabditis elegans model. Methanolic extracts of C. crispus (CCME) enhanced C. elegans tolerance to juglone-induced oxidative stress and increased life span; however water extracts did not show such effects. CCME treatment reduced reactive oxygen species (ROS) in the worms and increased the transcription of stress response genes; sod3, hsp16.2, daf16 and skn1. The chemical profile of CCME revealed the presence of unsaturated fatty acids, pigments, galactolipids, floridoside, isothionic acid, taurine, phenylalanine and l-citruline. Bioassay guided fractionation revealed that fatty acids, lipids and pigments imparted stress tolerance. Taken together, our results suggest that organic fractions of cultivated C. crispus impart oxidative stress tolerance in C. elegans, possibly by altering the stress response pathways.
Publication date
PublisherElsevier
LanguageEnglish
AffiliationNational Research Council Canada; Aquatic and Crop Resource Development
Peer reviewedYes
NRC number55475
NPARC number21268618
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Record identifier2d27dd87-375e-496a-bef3-57f66446773f
Record created2013-10-28
Record modified2016-05-09
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