Clusters of superparamagnetic iron oxide nanoparticles encapsulated in a hydrogel: a particle architecture generating a synergistic enhancement of the T2 relaxation

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DOIResolve DOI: http://doi.org/10.1021/nn2002272
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TypeArticle
Journal titleACS Nano
Volume5
Issue4
Pages31043112; # of pages: 9
Subjectsuperparamagnetic iron oxide nanoparticles; transverse relaxation; contrast agent; hydrogel; pH-responsive; particle coating
AbstractClusters of iron oxide nanoparticles encapsulated in a pH-responsive hydrogel are synthesized and studied for their ability to alter the T2-relaxivity of protons. Encapsulation of the clusters with the hydrophilic coating is shown to enhance the transverse relaxation rate by up to 85% compared to clusters with no coating. With the use of pH-sensitive hydrogel, difficulties inherent in comparing particle samples are eliminated and a clear increase in relaxivity as the coating swells is demonstrated. Agreement with Monte Carlo simulations indicates that the lower diffusivity of water inside the coating and near the particle surface leads to the enhancement. This demonstration of a surface-active particle structure opens new possibilities in using similar structures for nanoparticle-based diagnostics using magnetic resonance imaging.
Publication date
LanguageEnglish
AffiliationNRC Steacie Institute for Molecular Sciences; NRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NPARC number19663207
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Record identifier2d58b2f4-335f-4bbf-8361-8ca890cde363
Record created2012-03-16
Record modified2016-05-09
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