L-Fucose utilization provides Campylobacter jejuni with a competitve advantage

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DOIResolve DOI: http://doi.org/10.1073/pnas.1014125108
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TypeArticle
Journal titlePNAS
Volume108
Issue17
Pages71947199; # of pages: 6
Subjectpathogenesis; metabolism; qut; mucus
AbstractCampylobacter jejuni is a prevalent gastrointestinal pathogen in humans and a common commensal of poultry. When colonizing its hosts, C. jejuni comes into contact with intestinal carbohydrates, including l-fucose, released from mucin glycoproteins. Several strains of C. jejuni possess a genomic island (cj0480c–cj0490) that is up-regulated in the presence of both l-fucose and mucin and allows for the utilization of l-fucose as a substrate for growth. Strains possessing this genomic island show increased growth in the presence of l-fucose and mutation of cj0481, cj0486, and cj0487 results in the loss of the ability to grow on this substrate. Furthermore, mutants in the putative fucose permease (cj0486) are deficient in fucose uptake and demonstrate a competitive disadvantage when colonizing the piglet model of human disease, which is not paralleled in the colonization of poultry. This identifies a previously unrecorded metabolic pathway in select strains of C. jejuni associated with a virulent lifestyle.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NPARC number19254204
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Record identifier2d89f158-7760-4c13-8da1-c6f3c32adf41
Record created2012-03-08
Record modified2016-05-09
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