The cell motility modulator Slit2 is a potent inhibitor of platelet function

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DOIResolve DOI: http://doi.org/10.1161/CIRCULATIONAHA.112.105452
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TypeArticle
Journal titleCirculation
ISSN0009-7322
Volume126
Pages13851395; # of pages: 11
Subjectblood cells; blood platelets; thrombosis
AbstractBackground—Vascular injury and atherothrombosis involve vessel infiltration by inflammatory leukocytes, migration of medial vascular smooth muscle cells to the intimal layer, and ultimately acute thrombosis. A strategy to simultaneously target these pathological processes has yet to be identified. The secreted protein, Slit2, and its transmembrane receptor, Robo-1, repel neuronal migration in the developing central nervous system. More recently, it has been appreciated that Slit2 impairs chemotaxis of leukocytes and vascular smooth muscle cells toward diverse inflammatory attractants. The effects of Slit2 on platelet function and thrombus formation have never been explored.
Publication date
PublisherAmerican Heart Association
LanguageEnglish
AffiliationHuman Health Therapeutics; National Research Council Canada
Peer reviewedYes
NRC number53204
NPARC number21268297
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Record identifier2ea65dd3-828d-4158-b258-a90be168c360
Record created2013-06-17
Record modified2016-05-09
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