Magnetically alignable phase of phospholipid "bicelle" mixtures is a chiral nematic made up of wormlike micelles

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DOIResolve DOI: http://doi.org/10.1021/la048641l
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TypeArticle
Journal titleLangmuir
Langmuir
ISSN0743-7463
Volume20
Issue19
Pages78937897; # of pages: 5
AbstractWe have studied the phase behavior of binary mixtures of long- and short-chain lipids, namely, dimyristoyl phosphatidylcholine (DMPC) and dihexanoyl phosphatidylcholine (DHPC), using optical microscopy and small-angle neutron scattering. Samples with a total lipid content of 25 wt %, corresponding to ratios Q ([DMPC]/[DHPC]) of 5, 3.2, and 2, are found to exhibit an isotropic (I) chiral nematic (N*) lamellar phase sequence on increasing temperature. The I-N* transition coincides with the chain melting transition of DMPC at Q = 5 and 3.2, but the N* phase forms at a higher temperature for Q = 2. All three samples form multilamellar vesicles in the lamellar phase. Our results show that disklike "bicellar" aggregates occur only in the lower temperature isotropic phase and not in the higher temperature magnetically alignable N* phase, where they were previously believed to exist. The N* phase is found to consist of long, flexible wormlike micelles, their entanglement resulting in the very high viscosity of this phase.
Publication date
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
Identifier10367391
NPARC number12333603
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Record identifier2f8386e7-6e61-449d-90c1-e22ba29758d0
Record created2009-09-10
Record modified2016-05-09
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