Unique multimeric immunoglobulin crosslinking in four species from the family Gadidiae

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DOIResolve DOI: http://doi.org/10.1016/j.fsi.2005.11.004
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TypeArticle
Journal titleFish & Shellfish Immunology
Volume21
Issue2
Pages215219; # of pages: 5
Subjectimmunoglobulin; quaternary structure; gadid; haddock; cod
AbstractTetrameric immunoglobulin (lg) in most teleosts is a fully disulphide cross-linked molecule. The multimeric lg from four species from the order Gadiformes; haddock (Melanogrammus aeglefinus L.), Atlantic cod (Gadus morhua L), pollock (Pollachius pollachius L.) and tusk (Brosme bromse A.) was examined by denaturing, non-reducing gel electrophoresis and gel filtration chromatography. Despite having a native molecular mass equivalent to that of other tetrameric teleost lg, gadid lg was never observed to exist as a fully disulphide cross-linked molecule; existing instead as a covalently cross-linked trimer with a non-covalently associated monomer. It is unknown whether this unique cross-linking is associated with the limited or absent specific humoral responses reported for members of this order.
Publication date
PublisherElsevier
Copyright noticeCrown copyright © 2005
LanguageEnglish
AffiliationNRC Institute for Marine Biosciences; National Research Council Canada; NRC Institute for Nutrisciences and Health
Peer reviewedYes
NRC number1492
NPARC number3538560
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Record identifier31d22603-e2e7-4357-a8b7-75539fd6f594
Record created2009-03-01
Record modified2016-05-09
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