Exploring new chemical space by stereocontrolled diversity-oriented synthesis

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DOIResolve DOI: http://doi.org/10.1016/j.chembiol.2005.01.011
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TypeArticle
Journal titleChemistry & Biology
Volume12
Issue2
Pages163180; # of pages: 18
AbstractNatural products that act as highly specific, small-molecule protein-binding agents and as modulators of protein-protein interactions are highly complex and exhibit functional groups with three-dimensional and stereochemical diversity. The complex three-dimensional display of chiral functional groups appears to be crucial for exhibiting specificity in protein binding and in differentiating between closely related proteins. The development of methods that allow a high-throughput access to three-dimensional, skelatally complex, polycyclic compounds having few asymmetric diversity sites is essential and a highly challenging task. In the postgenomic chemical biology age, in which there is a great desire to understand protein-protein interactions and to dissect protein networking-based signaling pathways by small molecules, the need for developing "stereocontrolled, diversity-oriented synthesis" methods to generate natural product like libraries is of utmost importance.
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LanguageEnglish
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
NPARC number12341000
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Record identifier32ce980e-b5bc-4d05-ab3a-1c37aa11ccbf
Record created2009-09-11
Record modified2016-05-09
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