Biocompatible carbohydrate-functionalized stainless steel surfaces: a new method for passivating biomedical implants

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DOIResolve DOI: http://doi.org/10.1021/am200158y
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TypeArticle
Journal titleACS Applied Materials and Interfaces
ISSN1944-8244
Volume3
Issue5
Pages16011612; # of pages: 12
Subject316L stainless steel; atomic layer deposition; silica coating; trialkoxysilane surface functionalization; poly(ethylene glycol); carbohydrate
AbstractA convenient method for passivating and functionalizing stainless steel is described. Several methods of coating stainless steel (SS) samples with silica were investigated and of these methods, a thin (less than 15 nm thick) layer of silica created by atomic layer deposition (ALD) was found to give superior performance in electrochemical testing. These interfaces were then used as a platform for further functionalization with molecules of biological interest. Specifically, the SS samples were functionalized with biologically significant carbohydrates [N-acetyl-D-glucosamine (GlcNAc) and D-galactose (Gal)] that contain trialkoxysilane derivatives as chemical handles for linking to the surface. The presence and biological availability of these moieties on the silica coated SS were confirmed by XPS analysis and an enzyme-linked lectin assay (ELLA) using complementary lectins that specifically recognize the surface-bound carbohydrate. This method has the potential of being adapted to the functionalization of stainless steel biomedical implants with other biologically relevant carbohydrates. © 2011 American Chemical Society.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); National Institute for Nanotechnology
Peer reviewedYes
NPARC number21271915
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Record identifier32e4b8d3-cb94-46e6-8038-cec316d58f89
Record created2014-05-05
Record modified2016-05-09
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