APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease

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DOIResolve DOI: http://doi.org/10.4103/1673-5374.130117
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TypeArticle
Journal titleNeural Regeneration Research
ISSN1876-7958
Volume9
Issue6
Pages653660; # of pages: 8
Subjectaged; Alzheimer disease; apolipoprotein CI gene; apolipoprotein E gene; article; cognition; cognitive defect; cohort analysis; disease association; disease course; DNA extraction; DNA polymorphism; female; follow up; gel electrophoresis; gene; gene frequency; gene interaction; genotype; human; longitudinal study; low density lipoprotein receptor related protein gene; major clinical study; male; outcome assessment; polymerase chain reaction; rating scale; restriction fragment length polymorphism; scoring system; ultraviolet spectrophotometry
AbstractCurrent evidence shows that apolipoprotein E (APOE), apolipoprotein CI (APOC1) and low density lipoprotein receptor-related protein (LRP) variations are related to late-onset Alzheimer's disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer's disease patients. We performed a 30-month longitudinal cohort study to investigate the relationship between Alzheimer's disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer's disease were recruited form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess patients' cognitive function. After a 30-month follow-up period, we found a significant reduction in Mini-Mental State Examination total score, a higher proportion of patients fulfilling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOE ε4 carriers compared with non-carriers. In addition, the APOE ε4 allele frequency was significantly higher in the cognitive impairment progression group compared with the non-cognitive impairment progression group. In conclusion, APOE ε4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE ε4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer's disease.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); Human Health Therapeutics (HHT-TSH)
Peer reviewedYes
NPARC number21272156
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Record identifier335806c6-f8ba-48f0-87f0-d95483867c79
Record created2014-07-23
Record modified2016-05-09
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