Population differences in nerve resistance to paralytic shellfish toxins in softshell clam, Mya arenaria, associated with sodium channel mutations

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DOIResolve DOI: http://doi.org/10.1007/s00227-006-0432-z
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TypeArticle
Journal titleMarine Biology
ISSN0025-3162
Volume150
Issue6
Pages12271236; # of pages: 10
Subjectmutation; nerves; nucleotide sequence; saxitoxin; sodium channels; sodium channels (voltage-gated); toxins; genomics; mRNA; Alexandrium Bivalvia; Mya arenaria
AbstractThe softshell clam, Mya arenaria, is a commercially important bivalve with wide latitudinal distribution in North America. Populations of clams with a history of repeated exposure to toxic Alexandrium spp. have developed a natural resistance to the paralytic shellfish toxins (PSTs) produced by these algae. An association between PST resistance in individual clams and a single mutation in the saxitoxin (STX) binding region of the -subunit of the voltage-gated sodium (Na+) channel gene was previously identifed. Here we establish that more than one mutation associated with nerve resistance to STX occurred at this locus. Both cDNA from mRNA and genomic DNA sequences from individual clams are identical demonstrating that both alleles are expressed simultaneously. In addition, one resistant allele per individual is suYcient to confer neural resistance to STX even though heterozygous individuals show an intermediate level of resistance to STX in in vitro nerve trunk assays.
Publication date
PublisherSpringer-Verlag
Copyright notice© Springer-Verlag 2006
LanguageEnglish
AffiliationNRC Institute for Marine Biosciences; National Research Council Canada
Peer reviewedYes
NRC number1223
55853
NPARC number3538035
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Record identifier343e0527-1ee7-45a3-a5b6-a1c11075e4de
Record created2009-03-01
Record modified2016-05-09
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