Cerebral ischemia disrupts the expression of regulators of synaptic cell adhesion in synaptosomes

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DOIResolve DOI: http://doi.org/10.1038/sj.jcbfm.9591524.0219
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TypeBook Chapter
Book titleJournal of Cerebral Blood Flow and Metabolism
ISSN0271-678X
Volume25
PagesS219
Subjectcerebral ischemia; synaptic cell adhesion; synaptosomes
AbstractDramatic and rapidly reversible structural changes are observed in dendritic spine morphology following excitotoxic or hypoxic stress1. However, morphological and biochemical alterations in post-synaptic densities persist for up to 24 hours following transient ischemia. This suggests that the synapse may be the origin of signals that propagate toward the cell body and instigate delayed post-ischemic neuronal death. Synaptically localized cell adhesion molecules are important regulators of synaptic plasticity and synaptogenesis. Regulation of cell adhesion and cytoskeletal structure in dendritic spines is necessary for the maintenance of mature synaptic connections. Therefore, we examined the effects of transient cerebral ischemia on the expression of synaptic proteins 20 hours post-ischemia.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Biological Sciences
Peer reviewedYes
NPARC number21275190
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Record identifier348059b4-6acf-4a6c-833e-8918051cfd73
Record created2015-05-22
Record modified2016-05-09
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