Myocardial salvage with trolox and ascorbic acid for an acute evolving infarction

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DOIResolve DOI: http://doi.org/10.1016/0003-4975(89)90431-1
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TypeArticle
Journal titleThe Annals of Thoracic Surgery
ISSN0003-4975
Volume47
Issue4
Pages553557; # of pages: 5
Subjectalpha tocopherol; ascorbic acid; catalase; edetic acid; superoxide dismutase; trolox c; animal cell; dog; heart infarction; heart infarction size; intracardiac drug administration; necrosis; nonhuman; priority journal; Animal; Antioxidants; Ascorbic Acid; Benzopyrans; Cells, Cultured; Chromans; Disease Models, Animal; Dogs; Free Radicals; Heart; Hemodynamics; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Necrosis; Support, Non-U.S. Gov't
AbstractBoth Trolox (a water-soluble analogue of α-tocopherol) and ascorbic acid were more effective than superoxide dismutase or catalase in protecting myocyte cell cultures from free radical attack (induced by hypoxanthine and xanthine oxidase). In a canine model of two hours of left anterior descending coronary artery occlusion followed by four hours of reperfusion, Trolox and ascorbic acid reduced the area of infarction within the area at risk. The Trolox group received 500 mL of deoxygenated saline solution containing 2.0 g of Trolox, 3.0 g of ascorbic acid, and 18 mg of EDTA (ethylenediaminetetraacetic acid) infused into the ascending aorta 30 seconds before and four minutes after reperfusion. Saline controls received 500 mL of deoxygenated saline solution containing 18 mg of EDTA. The angioplasty group had unmodified reperfusion by simple release of the occlusion. The area at risk and the area infarcted were estimated with Evans blue and triphgnyl tetrazolium hydiochloride stains, respectively. The ratio of the area infarcted to the area at risk was significantly lower with Trolox (angioplasty, 33.4% ± 5.1%; saline, 20.8% ± 2.9%; and Trolox, 8.7% ± 4.0%; p < 0.01). In summary, the antioxidants Trolox and ascorbic acid effectively reduced myocardial necrosis after ischemia. © 1989.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21276738
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Record identifier367cbf24-6f02-4489-8a2d-d71dddbd23c8
Record created2015-10-13
Record modified2016-05-09
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