American ginseng inhibits vascular smooth muscle cell proliferation via suppressing Jak/Stat pathway

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DOIResolve DOI: http://doi.org/10.1016/j.jep.2012.09.046
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TypeArticle
Journal titleJournal of Ethnopharmacology
ISSN0378-8741
Volume144
Issue3
Pages782785
SubjectPanax quinquefolius; American ginseng; Jak; Stat; Vascular smooth muscle cells; Proliferation
AbstractEthnopharmcological relevance - Ginseng, a folk medicine which has been used for thousands of years in Asia, has been promoted for the treatment or prevention of health problems including cardiovascular disease. However, the molecular mechanism of ginseng-induced cardiovascular protection is unclear. Thus, we investigated signaling mechanism by which American ginseng inhibits vascular smooth muscle cell (VSMC) proliferation, a key feature of diverse vascular disease. Materials and methods - A standardized crude extract of American ginseng was supplied by the National Research Council of Canada, Institute for National Measurement Standards. Rat aortic smooth muscle cells (RASMCs) were exposed to fetal bovine serum (FBS), platelet derived growth factor (PDGF), insulin, or angiotensin II (Ang II) to induce proliferation that was examined by measuring DNA synthesis and cell numbers. Western blot was applied to determine the activations of Jak, Stat, Akt, and ERK. Results - American ginseng inhibited RASMC proliferation induced by FBS, PDGF, insulin or Ang II. American ginseng slightly increased both basal and FBS-, PDGF- or Ang II-induced activities of Akt and ERK in RASMCs; however, it dramatically inhibited the activation of Jak2 and Stat3. Conclusion - These results demonstrate that American ginseng inhibits VSMC proliferation through suppressing the Jak/Stat pathway.
Publication date
LanguageEnglish
AffiliationMeasurement Science and Standards; National Research Council Canada
Peer reviewedYes
IdentifierS037887411200654X
NPARC number21268786
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Record identifier36c162c1-79bd-4b06-aee3-a35e274bb576
Record created2013-11-13
Record modified2016-05-09
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