Never take candy from a stranger : The role of the bacterial glycome in host–pathogen interactions

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DOIResolve DOI: http://doi.org/10.2217/fmb.09.103
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TypeArticle
Journal titleFuture Microbiology
Volume5
Pages267288; # of pages: 22
AbstractWith the comprehensive study and complete sequencing of the Haemophilus influenzae genome in 1995 came the term ‘genomics’ and the beginning of the ‘omics’ era. Since this time, several analogous fields, such as transcriptomics and proteomics, have emerged. While growth and advancement in these fields have increased understanding of microbial virulence, the study of bacterial glycomes is still in its infancy and little is known concerning their role in host–pathogen interactions. Bacterial glycomics is challenging owing to the diversity of glyco-conjugate molecules, vast array of unusual sugars and limited number of analytical approaches available. However, recent advances in glycomics technologies offer the potential for exploration and characterization of both the structures and functions of components of bacterial glycomes in a systematic manner. Such characterization is a prerequisite for discerning the role of bacterial glycans in the interaction between host defences and bacterial virulence factors.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NPARC number17512530
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Record identifier37656892-bc94-42f3-b6e3-ab828518a394
Record created2011-03-30
Record modified2016-05-09
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