Silicon photonic wire biosensor array for multiplexed, real-time and label-free molecular detection

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DOIResolve DOI: http://doi.org/10.1364/OL.34.003598
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TypeArticle
Journal titleOptics Letters
Volume34
Issue23
Pages35983600; # of pages: 3
Subjectsilicon; photonic wire; waveguide; biosensor; array chip; monitoring; binding reactions
AbstractWe demonstrate a silicon photonic wire waveguide biosensor array chip for the simultaneous monitoring of different molecular binding reactions. The chip is compatible with automated commercial spotting tools and contains a monolithically integrated microfluidic channel for sample delivery. Each array sensor element is a 1.8-mm-long spiral waveguide folded within a 130 µm diameter spot and is incorporated in a balanced Mach–Zehnder interferometer with a near temperature independent response. The sensors are arranged in a 400 µm spacing grid pattern and are addressed through cascaded 1x2 optical power splitters using light from a single input fiber. We demonstrate the real-time monitoring of antibody–antigen reactions using complementary and mismatched immunoglobulin G receptor–analyte pairs and bovine serum albumin. The measured level of detection for each sensor element corresponds to a surface coverage of less than 0.3 pg/mm².
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Institute for Microstructural Sciences; NRC Steacie Institute for Molecular Sciences; NRC Institute for Biological Sciences
Peer reviewedYes
NPARC number15329309
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Record identifier37a446c4-3af0-4f01-98ab-bb6b3c28bdb1
Record created2010-05-21
Record modified2016-05-09
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