Alzheimer's disease : neuritic plaques and neurofibrillary tangles in human brain identified by FTIR spectroscopy

DOIResolve DOI: http://doi.org/10.1117/12.166733
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TypeBook Chapter
Proceedings title9th International Conference on Fourier Transform Spectroscopy
Series titleProceedings of SPIE - The International Society for Optical Engineering
Conference9th International Conference on Fourier Transform Spectroscopy, August 23, 1993, Calgary, Alberta, Canada
Volume2089
Pages134135; # of pages: 2
AbstractThe abnormal abundance of (beta) -amyloid plaques and neurofibrillary tangles are the hallmark of Alzheimer's disease (AD). Human central nervous system (CNS) grey matter was probed for characteristics arising from these pathological features. In AD but not normal grey matter, an IR band at 1615 cm-1 is seen, characteristic of a protein in an aggregated state. We speculate that this band arises from (beta) A4-amyloid protein. AD, and 18q- grey matter spectra show increased intensity of phosphate bands in accordance with known hyperphosphorylation of proteins found in neurofibrillary tangles. These spectral features may be useful in the diagnosis of AD.
Publication date
PublisherSPIE
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Biodiagnostics
Peer reviewedYes
NRC number3
NPARC number9743009
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Record identifier37d7789b-3268-4d9a-a02e-dd1cf52690cd
Record created2009-07-17
Record modified2016-12-09
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