Oligosaccharide fragments of the type III group B streptococcal polysaccharide derived from S. pneumoniae type 14 capsular polysaccharide by a chemoenzymatic method

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DOIResolve DOI: http://doi.org/10.1016/S0008-6215(98)00134-7
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TypeArticle
Journal titleCarbohydrate Research
Volume309
Issue3
Pages297301; # of pages: 5
AbstractPartial N-deacetylation of the GlcNAc residues in S. pneumoniae type 14 capsular polysaccharide (Pn14-PS) backbone was achieved by treatment with base, and the product was subsequently enzymatically sialylated at the 3-O-positions of the terminal galactose residues. The resultant, partially N-deacetylated type III Group B streptococcus capsular polysaccharide (GBSIII-PS) was subjected to nitrous acid deamination, which resulted in the degradation of GBSIII-PS polysaccharide into oligosaccharides containing increasing numbers of the identical repeating units. The oligosaccharides were then separated by passage through a Superdex 30 column and characterized by ESIMS and NMR spectroscopic analysis.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedNo
NRC numberZOU1998
NPARC number9372197
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Record identifier3a857eea-a7ee-49f5-a189-1ad8ae43aa15
Record created2009-07-10
Record modified2016-05-09
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