Implantable Electrochemical Sensors for Biomedical and Clinical Applications: Progress, Problems, and Future Possibilities.

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TypeArticle
Journal titleCurrent Medicinal Chemistry
ISSN0929-8673
Volume14
Issue8
Pages937951; # of pages: 15
Subjectimplantable eletrochemial sensor; glucose; blood gases; electrolyte; biomaterials; In vivo monitoring; biocompatibility; device; membrane
AbstractBiosensors are of great interest for their ability to monitor clinically important analytes such as blood gases, electrolytes, and metabolites. A classic example is to monitor the dynamics of blood-glucose levels for treating diabetes. However, the current practice, based on a three decade old technology, requires a drop of blood on a test strip, which is in dire need of replacement. The increasing demands and interests in developing implantable glucose sensors for treating diabetes has led to notable progress in this area, and various electrochemical sensors have been developed for intravascular and subcutaneous applications. However, implantations are plagued by biofouling, tissue destruction and infection around the implanted sensors and the response signals must be interpreted in terms of blood or plasma concentrations for clinical utility, rather than tissue fluid levels. This review focuses on the potentials and pitfalls of implantable electrochemical sensors and presents our opinions about future possibilities of such implantable devices with respect to biocompatibility issues, long-term calibration, and other aging effects on the sensors.
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LanguageEnglish
Peer reviewedNo
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Identifier10522645
20070410122611252
NPARC number3539097
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Record identifier3ae3e6f9-bc9d-4902-8f0d-0ed2ccd84ae4
Record created2009-03-01
Record modified2016-05-09
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