Hypoglycemic effect of Aemotoxylon campechanum on streptozotocin (STZ)-induced diabetic rats

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TypeArticle
Journal titleJournal of Traditional Medicines
ISSN1340-6302
Volume20
Issue2
Pages5761; # of pages: 5
SubjectAematoxylon campechanum; hypoglycemic effect; streptozotocin; guainane-type sesquiterpene; coumarin
AbstractHypoglycemic activity of Aemotoxylon campechanum was examined in STZ-induced diabetic rats. The water extract of A. campechanum lowered fasting blood glucose level of STZ-induced diabetic rats significantly and dosedependently. The water extract further divided into MeOH and H_2O-soluble fractions. The MeOH-soluble fraction showed the strongest hypoglycemic effect, which lowered fasting blood glucose level by 37% at a dose of 100 mg/kg (i. p.). The water extract and the MeOH-soluble fraction were found to be more effective in lowering the blood glucose level of diabetic rats than the mixtures of tolbutamide (200 mg/kg) and buformin (1 mg/kg) used as positive control, which lowered blood glucose level by 35.1%. The active fraction led to isolation of five guainane-type sesquiterpenes and a coumarin derivative.
Publication date
Linkhttp://ci.nii.ac.jp/naid/110001846587
LanguageEnglish
Peer reviewedYes
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NPARC number21274351
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Record identifier3b8958d8-2ec8-419b-9816-0cced9fbadf7
Record created2015-03-10
Record modified2016-05-09
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