Dimyristoyl phosphatidylcholine: A remarkable exception to α-tocopherol's membrane presence

Download
  1. Get@NRC: Dimyristoyl phosphatidylcholine: A remarkable exception to α-tocopherol's membrane presence (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1021/ja408288f
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleJournal of the American Chemical Society
ISSN0002-7863
Volume136
Issue1
Pages203210; # of pages: 8
AbstractUsing data obtained from different physical techniques (i.e., neutron diffraction, NMR and UV spectroscopy), we present evidence which explains some of the conflicting and inexplicable data found in the literature regarding α-tocopherol's (aToc's) behavior in dimyristoyl phosphatidylcholine (di-14:0PC) bilayers. Without exception, the data point to aToc's active chromanol moiety residing deep in the hydrophobic core of di-14:0PC bilayers, a location that is in stark contrast to aToc's location in other PC bilayers. Our result is a clear example of the importance of lipid species diversity in biological membranes and importantly, it suggests that measurements of aToc's oxidation kinetics, and its associated byproducts observed in di-14:0PC bilayers, should be reexamined, this time taking into account its noncanonical location in this bilayer. © 2013 American Chemical Society.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Canadian Neutron Beam Centre (CNBC-CCFN)
Peer reviewedYes
NPARC number21270831
Export citationExport as RIS
Report a correctionReport a correction
Record identifier3bf57187-7321-4b2e-a1c1-9a06b58ce473
Record created2014-02-17
Record modified2017-03-23
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)