Clavulanic acid inhibition of β-lactamase 1 from Bacillus cereus 569/H

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TypeArticle
Journal titleJ. Antibiot. (Tokyo)
Volume31
Issue11
Pages11621169; # of pages: 8
AbstractInactivation of beta-lactamase I by clavulanic acid was investigated. Clavulanic acid induced inhibition of the enzyme was found to be progressive with time. Benzylpenicillin provided protection against the adverse effects of the inhibitor initially, however, the enzyme was irreversibly inhibited in a progressive manner even in the presence of substrate. Reaction of beta-lactamase I with clavulanic acid, in the presence of ampicillin, led to a very rapid inactivation of the enzyme.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedNo
NRC numberDURKIN1979
NPARC number9379631
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Record identifier3cd79bfd-2bda-4921-ba6e-459891439fed
Record created2009-07-10
Record modified2016-05-09
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