Drosophila melanogaster Thor and Response to Candida albicans Infection

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DOIResolve DOI: http://doi.org/10.1128/EC.00346-06
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TypeArticle
Journal titleEukaryotic Cell
Volume6
Issue4
Pages658663; # of pages: 6
Subjectanalysis; Candida; Candida albicans; Cells; Drosophila; Drosophila melanogaster; Genes; genome; pha; Up-Regulation
AbstractWe used Drosophila melanogaster macrophage-like Schneider 2 (S2) cells as a model to study cell-mediated innate immunity against infection by the opportunistic fungal pathogen Candida albicans. Transcriptional profiling of S2 cells coincubated with C. albicans cells revealed up-regulation of several genes. One of the most highly up-regulated genes during this interaction is the D. melanogaster translational regulator 4E-BP encoded by the Thor gene. Analysis of Drosophila 4E-BP(null) mutant survival upon infection with C. albicans showed that 4E-BP plays an important role in host defense, suggesting a role for translational control in the D. melanogaster response to C. albicans infection
Publication date
AffiliationNRC Biotechnology Research Institute; National Research Council Canada
Peer reviewedNo
NRC number47513
NPARC number3538939
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Record identifier3cf8355d-d04e-4c6e-82c0-dec36eaa6390
Record created2009-03-01
Record modified2016-05-09
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