White versus gray matter : fMRI hemodynamic responses show similar characteristics, but differ in peak amplitude

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DOIResolve DOI: http://doi.org/10.1186/1471-2202-13-91
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TypeArticle
Journal titleBMC Neuroscience
Volume13
Issue1
Pages91
Subjectwhite matter; functional connectivity; BOLD response; hemodynamic response function; event-related
AbstractBACKGROUND: There is growing evidence for the idea of fMRI activation in white matter. In the current study, we compared hemodynamic response functions (HRF) in white matter and gray matter using 4 T fMRI. White matter fMRI activation was elicited in the isthmus of the corpus callosum at both the group and individual levels (using an established interhemispheric transfer task). Callosal HRFs were compared to HRFs from cingulate and parietal activation. RESULTS: Examination of the raw HRF revealed similar overall response characteristics. Finite impulse response modeling confirmed that the WM HRF characteristics were comparable to those of the GM HRF, but had significantly decreased peak response amplitudes. CONCLUSIONS: Overall, the results matched a priori expectations of smaller HRF responses in white matter due to the relative drop in cerebral blood flow (CBF) and cerebral blood volume (CBV). Importantly, the findings demonstrate that despite lower CBF and CBV, white matter fMRI activation remained within detectable ranges at 4 T.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NPARC number20496815
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Record identifier3dcf8692-cb2d-42d4-b660-09428a989f41
Record created2012-08-16
Record modified2016-05-09
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