Label-free, fluorescence detection of DNA on nanoparticle scaffolds

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TypeArticle
ConferenceNSTI-Nanotech 2010. Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, Anaheim, CA
SubjectDNA; label-free detection; nanoparticle; polymeric transduction
AbstractWe have developed a nanoparticle-based DNA biosensor that can detect unlabelled ssDNA with good sensitivity (picomolar concentrations). The biosensor makes use of the optical changes of a cationic polymer interacting with ssDNA versus that of hybridized DNA to provide a fluorescence signal only when a specific hybridization event occurs (i.e. only when perfectly complementary DNA is present)
Publication date
Linkhttp://materiales.azc.uam.mx/area/Ingenieria_Materiales/investigaci%C3%B3n/2261204/cuan%20calif/Cuan%20TechConWo2010/CD/Nanotech2010/934.html
LanguageEnglish
AffiliationNRC Steacie Institute for Molecular Sciences; National Research Council Canada
Peer reviewedYes
NPARC number17653084
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Record identifier3df622cc-b0f8-4e2f-a654-74cf2fd389ac
Record created2011-04-01
Record modified2016-05-09
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