Simulations of interdigitated electrode interactions with gold nanoparticles for impedance-based biosensing applications

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DOIResolve DOI: http://doi.org/10.3390/s150922192
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TypeArticle
Journal titleSensors
ISSN1424-8220
Volume15
Issue9
Pages2219222208
SubjectCOMSOL; biosensor; gold nanoparticles; interdigitated electrodes
AbstractIn this paper, we describe a point-of-care biosensor design. The uniqueness of our design is in its capability for detecting a wide variety of target biomolecules and the simplicity of nanoparticle enhanced electrical detection. The electrical properties of interdigitated electrodes (IDEs) and the mechanism for gold nanoparticle-enhanced impedance-based biosensor systems based on these electrodes are simulated using COMSOL Multiphysics software. Understanding these properties and how they can be affected is vital in designing effective biosensor devices. Simulations were used to show electrical screening develop over time for IDEs in a salt solution, as well as the electric field between individual digits of electrodes. Using these simulations, it was observed that gold nanoparticles bound closely to IDEs can lower the electric field magnitude between the digits of the electrode. The simulations are also shown to be a useful design tool in optimizing sensor function. Various different conditions, such as electrode dimensions and background ion concentrations, are shown to have a significant impact on the simulations.
Publication date
PublisherMDPI
LanguageEnglish
AffiliationNational Institute for Nanotechnology; National Research Council Canada
Peer reviewedYes
NPARC number23001606
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Record identifier3fefe4d9-ac20-4e58-8f69-a193094e2dc5
Record created2017-03-09
Record modified2017-03-09
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