Nitric oxide delivery by core/shell superparamagnetic nanoparticle vehicles with enhanced biocompatibility

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DOIResolve DOI: http://doi.org/10.1021/la302357h
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TypeArticle
Journal titleLangmuir
ISSN0743-7463
1520-5827
Volume28
Issue35
Pages1287912885
AbstractWe report the synthesis of Fe3O4/silica core/shell nanoparticles and their functionalization with S-nitrosothiols. These nanoparticles are of immense interest because of their nitric oxide (NO) release capabilities in human alveolar epithelial cells. Moreover, they act as large storage reservoirs of NO that can be targeted magnetically to the specific site with a sustainable release of NO for up to 50 h. Such nanoparticles provide an enhancement of the biocompatibility with released NO while allowing intracellular accumulation ascribed to their small size.
Publication date
LanguageEnglish
AffiliationMedical Devices; National Research Council Canada
Peer reviewedYes
NPARC number21268903
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Record identifier42212114-dc41-4965-afbe-4b7fd27cc814
Record created2013-11-25
Record modified2016-05-09
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