Effect of Si and Fe doping on calcium phosphate glass fibre reinforced polycaprolactone bone analogous composites

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DOIResolve DOI: http://doi.org/10.1016/j.actbio.2011.12.030
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TypeArticle
Journal titleActa Biomaterialia
ISSN1742-7061
Volume8
Issue4
Pages16161626; # of pages: 11
SubjectPhosphate-based glass fibres; Biodegradable composites; Bioactivity; Preosteoblast; Tissue engineering
AbstractReinforcing biodegradable polymers with phosphate-based glass fibres (PGF) is of interest for bone repair and regeneration. In addition to increasing the mechanical properties, PGF can also release bioinorganics, as they are water soluble, a property that may be controllably translated into a fully degradable composite. Herein, the effect of Si and Fe on the solubility of calcium-containing phosphate-based glasses (PG) in the system (50P2O5–40CaO–(10 − x)SiO2−xFe2O3, where x = 0, 5 and 10 mol.%) were investigated. On replacing SiO2 with Fe2O3, there was an increase in the glass transition temperature and density of the PG, suggesting greater crosslinking of the phosphate chains. This significantly reduced the dissolution rates of degradation and ion release. Two PG formulations, 50P2O5–40CaO–10Fe2O3 (Fe10) and 50P2O5–40CaO–5Fe2O3–5SiO2 (Fe5Si5), were melt drawn into fibres and randomly incorporated into polycaprolactone (PCL). Initially, the flexural strength and modulus significantly increased with PGF incorporation. In deionized water, PCL–Fe5Si5 displayed a significantly greater weight loss and ion release compared with PCL–Fe10. In simulated body fluid, brushite was formed only on the surface of PCL–Fe5Si5. Dynamic mechanical analysis in phosphate buffered saline (PBS) at 37 °C revealed that the PCL–Fe10 storage modulus (E′) was unchanged up to day 7, whereas the onset of PCL–Fe5Si5 E′ decrease occurred at day 4. At longer-term ageing in PBS, PCL–Fe5Si5 flexural strength and modulus decreased significantly. MC3T3-E1 preosteoblasts seeded onto PCL–PGF grew up to day 7 in culture. PGF can be used to control the properties of biodegradable composites for potential application as bone fracture fixation devices.
Publication date
LanguageEnglish
AffiliationNRC Industrial Materials Institute; National Research Council Canada
Peer reviewedYes
IdentifierS1742706111005666
NPARC number21268621
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Record identifier425a7a51-931f-4a96-aca5-f1646de8d958
Record created2013-10-28
Record modified2016-05-09
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