Cloning and characterization of the Atlantic salmon serum lectin, a long-form C-type lectin expressed in kidney

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DOIResolve DOI: http://doi.org/10.1016/S0304-4165(03)00045-X
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TypeArticle
Journal titleBiochimica et Biophysica Acta - General Subjects
Volume1621
Issue1
Pages110115; # of pages: 6
SubjectLectin superfamily; Salmo salar; Salmon serum lectin
AbstractWe report the cloning of four distinct cDNAs and a genomic sequence encoding a multimeric serum lectin found in the blood of Atlantic salmon (Salmo salar). The sequence variation among the cDNAs as well as genomic Southern blotting analysis revealed a multi-gene family. Expression of the salmon serum lectin (SSL) was specific to kidney, as demonstrated by RT-PCR. Analysis of the 173-amino acid sequence of SSL confirmed that it is a member of the C-type lectin superfamily. Sequence alignments and intron/exon structure of the SSL gene showed it to belong to the type VII C-type lectins, which normally bind to galactose or other ligands, whereas the SSL protein sequence contains the EPN motif of mannose-binding C-type lectins, that bind mannose or related carbohydrates.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Marine Biosciences; NRC Institute for Biological Sciences
Peer reviewedYes
NRC numberNRC-IMB-42376
NPARC number21272064
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Record identifier429ab822-3f14-4085-b5d7-5b614ffea93f
Record created2014-06-16
Record modified2016-05-09
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