Recent advances in the development of novel mucosal adjuvants and antigen delivery systems

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DOIResolve DOI: http://doi.org/10.4161/hv.6.9.11561
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TypeArticle
Journal titleHuman Vaccines
Volume6
Issue9
Pages706714; # of pages: 9
AbstractMucosal infections and associated diseases remain a major socio-economic burden to society. Since parenteral immunizations fail to induce efficient protective immunity at mucosal surfaces, mucosal immunization is a logical approach to prevent and treat mucosally-initiated infections. All currently approved human mucosal vaccines are based on attenuated or killed whole pathogen cells but this strategy does pose safety concerns. Therefore, substantial effort is being invested to develop safe and effective mucosal adjuvants and delivery systems for mucosal vaccines. Encouragingly, some of these have progressed to advanced preclinical and clinical studies. This review discusses the promising preclinical research and the potential applications of several novel mucosal adjuvants and delivery systems: an archaeal lipid mucosal vaccine adjuvant and delivery (AMVAD) system, 3’,5’-cyclic diguanylic acid (c-di-GMP) and detoxified bacterial AB5 toxins. The potential and challenges in targeting M cells for mucosal vaccination are also discussed.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NPARC number17652981
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Record identifier4389a908-68ca-47c0-a2c6-984ae89e817c
Record created2011-04-01
Record modified2016-05-09
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