Structural elucidation of the novel type VII group B Streptococcus capsular polysaccharide by high resolution NMR spectroscopy: Carbohydr.Res.

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TypeArticle
Journal titleCarbohydr.Res.
Volume277
Issue1
Pages19; # of pages: 9
Subject13C; 13C-NMR; 1D; 1H; 2D; Acetylglucosamine; ACID; Acids; analysis; bacterial; Bacterial Capsules; Canada; capsular polysaccharide; capsule; Carbohydrate Conformation; Carbohydrate Sequence; chemistry; D-GLUCOSE; ELUCIDATION; Galactose; Glucose; group B Streptococcus; GROUP-B; HIGH-RESOLUTION; Magnetic Resonance Spectroscopy; Molar; Molecular Sequence Data; N-Acetylneuraminic Acid; NMR; NMR spectroscopy; NMR-spectroscopy; POLYSACCHARIDE; Polysaccharides; REPEATING UNIT; Repetitive Sequences,Nucleic Acid; RESOLUTION; Resolution Nmr Spectroscopy; SIALIC; Sialic Acids; SIALIC-ACID; SPECTROSCOPY; STRAIN; Streptococcus; Streptococcus agalactiae; STRUCTURAL; structural elucidation; UNIT
AbstractThe type VII capsular polysaccharide isolated from the newly discovered group B Streptococcus (GBS) strain contains D-glucose, D-galactose, N-acetyl-D-glucosamine and N-acetylneuraminic acid in the molar ratio 2:2:1:1. High-resolution one- and two-dimensional (1D and 2D) 1H and 13C NMR spectroscopy of the native and desialylated polysaccharides showed the type VII GBS capsular polysaccharide to contain the following branched hexasaccharide repeating unit: [formula: see text] Despite extensive structural similarity with the previously described GBS polysaccharides, the type VII polysaccharide showed no cross-reaction with the heterologous antisera
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedNo
NRC numberKOGAN1995
NPARC number9361350
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Record identifier43d22159-9357-4aab-9495-dc7186dd1b10
Record created2009-07-10
Record modified2016-05-09
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