Cytochalasin-B and phloretin depress contraction and relaxation of aortic smooth muscle

Download
  1. Get@NRC: Cytochalasin-B and phloretin depress contraction and relaxation of aortic smooth muscle (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1016/0014-2999(87)90514-0
AuthorSearch for: ; Search for:
TypeArticle
Journal titleEuropean Journal of Pharmacology
ISSN0014-2999
Volume144
Issue2
Pages153157
SubjectAorta; Cytochalasin-B; EDRF; Histamine; Noradrenaline; Phloretin; Sugar transport; (Contraction, Relaxation)
AbstractCytochalasin-B (20 μM) and phloretin (100 μM) blocked by more than 80% the contractile responses to calcium ions in partially depolarized rabbit aortic strips. Both also blocked, but only by approximately 50%, the responses to noradrenaline and histamine in normal calcium medium. The responses to these agonists in calcium-free EGTA medium were also blocked partially. Cytochalasin-B partially blocked the acetylcholine-induced relaxation of aortic strips precontracted with phenylephrine but not the relaxation due to nitroglycerine or compound A 23187. The relaxation due to isoprenaline was potentiated by cytochalasin B. Since both compounds are known to block hexose transport but share no other known effects, it is suggested that a glycolytic intermediate could be required for the contraction in response to calcium. However, the concentrations of cytochalasin-B required for these effects were somewhat greater than those usually required to block hexose transport.
Publication date
LanguageEnglish
AffiliationAquatic and Crop Resource Development; National Research Council Canada
Peer reviewedYes
NPARC number23000932
Export citationExport as RIS
Report a correctionReport a correction
Record identifier4426b491-aa17-46a1-a7f6-6a3efbd55cb4
Record created2016-11-17
Record modified2016-11-17
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)