Structural Phase Behavior of High-Concentration, Alignable Biomimetic Bicelle Mixtures

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DOIResolve DOI: http://doi.org/10.1002/masy.200550112
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TypeArticle
Journal titleMacromolecular Symposia
Volume219
Issue1
Pages135146; # of pages: 12
AbstractThe structures of bicelle mixtures composed of dimyristoyl and dihexanoyl phosphatidylcholines (DMPC and DHPC) with DMPC/DHPC molar ratios of 3.2 and 5 are characterized using polarized optical microscopy (POM) and small angle neutron scattering (SANS). Three phases, isotropic (I), chiral nematic (N*) and smectic (S) are observed as temperature (T) varies from 10 to 70 ?C. The structure of the magnetically alignable N* phase, which was previously considered to be made up of discoidal micelles, is found to be composed of ldquoribbonsrdquo. Doping with the charged lipid, dimyristoyl phosphatidylglycerol (DMPG), which has the same 14:0 hydrocarbon chains as DMPC, results in a structural change of the aggregates where only the isotropic and smectic phases are observed. The smectic phase for the mixtures doped with DMPG is shear-alignable and follows one-dimensional swelling. However, at high-T zwitterionic DMPC/DHPC mixtures form multi-lamellar vesicles (MLV) with a relatively constant lamellar spacing of 66 ?, independent of water content.
Publication date
AffiliationNational Research Council Canada; NRC Canadian Neutron Beam Centre
Peer reviewedNo
NPARC number12333681
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Record identifier450929cb-8fde-49ab-8fab-8e5d619b0e16
Record created2009-09-10
Record modified2016-05-09
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