Antimalarial activity of cassane- and norcassane-type diterpenes from Caesalpinia crista and their structure–activity relationship

Download
  1. Get@NRC: Antimalarial activity of cassane- and norcassane-type diterpenes from Caesalpinia crista and their structure–activity relationship (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1248/bpb.29.1050
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleBiological and Pharmaceutical Bulletin
ISSN0918-6158
1347-5215
Volume29
Issue5
Pages10501052; # of pages: 3
AbstractMalaria is one of the most life-threatening infectious diseases worldwide and claims the millions of peoples life each year. The appearance of drug-resistance Plasmodium falciparum has made the treatment of malaria increasingly problematic, and thus, it is a dire need to search the new alternatives of current drugs. In the present study, 44 cassane- and norcassane-type diterpenes isolated from Caesalpinia crista of Myanmar and Indonesia were evaluated for their antimalarial activity against the malaria parasite Plasmodium falciparum FCR-3/A2 clone in vitro. Most of the tested diterpenes displayed antimalarial activity, and norcaesalpinin E (28) showed the most potent activity with an IC50 value of 0.090 μM, more potent than the clinically used drug chloroquine (IC50, 0.29 μM). Based on the observed results, a structure–activity relationship has been established.
Publication date
LanguageEnglish
Peer reviewedYes
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NPARC number21274262
Export citationExport as RIS
Report a correctionReport a correction
Record identifier4537223a-9371-4ce7-bb6a-1653fbf4a675
Record created2015-03-06
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)
Date modified: