The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma

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DOIResolve DOI: http://doi.org/10.1016/0304-4165(87)90155-3
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TypeArticle
Journal titleBBA - General Subjects
ISSN0304-4165
Volume924
Issue3
Pages408419; # of pages: 12
Subjectalpha tocopherol; antioxidant; ascorbic acid; free radical; lipid peroxide; perhydroxyl radical; peroxide; plasma protein; uric acid; article; biosynthesis; blood; human; physiology; solubility; Antioxidants; Ascorbic Acid; Blood Proteins; Free Radicals; Human; Lipid Peroxides; Peroxides; Solubility; Support, Non-U.S. Gov't; Uric Acid; Vitamin E
AbstractThe Total (Peroxyl) Radical-trapping Antioxidant Parameter (TRAP) of six freshly prepared human plasma samples and 45 frozen plasma samples has been determined. It is shown that contributions from urate (35-65%), plasma proteins (10-50%), ascorbate (0-24%) and vitamin E (5-10%) to TRAP account for all of the peroxyl radical-trapping antioxidant activity in the majority of the samples. The changes in concentrations of the plasma antioxidants during peroxyl radical attack show that first line of defense is provided by the plasma sulfhydryl group, even urate being spared during the initial stages of the reaction. The modes of action of all of these plasma antioxidants and possible interactions between them are discussed, with particular emphasis on the abilities of the water-soluble antioxidants to regenerate or spare the only lipid-soluble antioxidant, vitamin E. © 1987.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21276506
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Record identifier45c4fb8a-832f-4d4d-ad8b-63c2933ef815
Record created2015-10-13
Record modified2016-05-09
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