Classification of infrared spectra of Alzheimer's Disease tissue by multivariate analyses

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DOIResolve DOI: http://doi.org/10.1007/978-94-011-0371-8_223
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TypeBook Chapter
Proceedings titleSpectroscopy of Biological Molecules
Conference6th European Conference on the Spectroscopy of Biological Molecules, September 3-8, 1995, Villeneuve d'Ascq, France
ISSN978-94-010-4166-9
978-94-011-0371-8
Pages487488; # of pages: 2
AbstractWe present a new approach to the classification of infrared (IR) data of Alzheimer's diseased (AD) tissue using several multivariate (MV) methods which could potentially be used in the diagnosis of AD from autopsy tissue. Alzheimer’s disease is the most common dementing disease of adult life causing disorientation in person, time and place. The histopathological hallmarks of AD are the formation of neuritic plaques (NP) and neurofibrillary tangles (NFT) in the grey matter regions of the brain. Neuritic plaques are roughly spherical consisting of a core of amyloid peptide (βA4-amyloid peptide) surrounded by irregular, loosely arranged aggregates of neuronal and glial processes.1 Neurofibrillary tangles are bundles of abnormal filaments composed of paired helical chains of hyperphosphorylated microtubule associated protein intertwined to form paired helical filaments.1 The abnormalities of NP and NFT serve as biochemical markers amenable to characterisation by IR spectroscopy and may provide diagnostic infrared signatures of AD tissue.
Publication date
PublisherKluwer Academic
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Biodiagnostics
Peer reviewedNo
NRC number421
NPARC number9721921
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Record identifier4639a76e-4577-4595-b23b-b266f7554ef6
Record created2009-07-17
Record modified2016-11-23
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