Five novel highly oxygenated diterpenes of Orthosiphon stamineus from Myanmar

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DOIResolve DOI: http://doi.org/10.1021/np000607t
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TypeArticle
Journal titleJournal of Natural Products
ISSN0163-3864
1520-6025
Volume64
Issue5
Pages592596; # of pages: 5
AbstractFive novel highly oxygenated diterpenes, orthosiphols K (1), L (2), M (3), and N (4) and norstaminone A (5), were isolated from the aerial part of Orthosiphon stamineus, together with three known diterpenes, orthosiphols A (6) and B (7) and neoorthosiphol A (8). Orthosiphol L (2) is an isopimarane-type diterpene with a hydroxyl group at C-12, which supports the biogenesis of staminane-type diterpenes, i.e., migration of a vinylic group from C-13 of isopimarane to C-12. Norstaminone A (5) has a staminane carbon framework and supports the biosynthetic pathway from staminols to norstaminols via staminolactones. All the isolated compounds showed mild to weak antiproliferative activities toward highly liver metastatic colon 26-L5 carcinoma and human HT-1080 fibrosarcoma cell lines.
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LanguageEnglish
Peer reviewedYes
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NPARC number21274808
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Record identifier47008919-1755-46c2-a409-e642af6bfcd3
Record created2015-04-13
Record modified2016-05-09
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