Placental infection by Salmonella enterica typhimurium in a murine model : mechanisms of pathogenesis and role of inflammatory cell death

Download
  1. Get@NRC: Placental infection by Salmonella enterica typhimurium in a murine model : mechanisms of pathogenesis and role of inflammatory cell death (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1016/j.placenta.2014.06.207
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Proceedings titlePlacenta
ConferenceInternational Federation of Placental Associations Conference (IFPA EPG 2014), Sept 9-12, 2014, Paris, France
ISSN0143-4004
Volume35
Issue9
PagesA64
AbstractPregnancy confers increased susceptibility to intracellular infections such as Salmonella enterica serovar Typhimurium (S. Tm). S. Tm infection during pregnancy in normally resistant mice (129X1/SvJ with a fully functional Nramp gene) leads to rapid severe placental inflammation followed by fetal and maternal death. However, the immune mechanism of feto-maternal interface inflammation has not been fully elucidated. The objective of this study was to test the hypothesis that the mechanism of trophoblast (TBC) cell death following infection, contributes to feto-maternal inflammation and adverse effects on the mother and fetus.
Publication date
LanguageEnglish
AffiliationHuman Health Therapeutics; National Research Council Canada
Peer reviewedYes
NRC numberNRC-HHT-53246
NPARC number21275376
Export citationExport as RIS
Report a correctionReport a correction
Record identifier477731c4-415a-4993-88ed-980c8c6f0f42
Record created2015-06-17
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)
Date modified: