Hepatoprotective and anti-Helicobacter pylori activities of constituents from Brazilian propolis

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DOIResolve DOI: http://doi.org/10.1078/0944-7113-00004
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TypeArticle
Journal titlePhytomedicine
ISSN0944-7113
Volume8
Issue1
Pages1623; # of pages: 8
SubjectBrazilian propolis; hepatoprotective activity; Helicobacter pylori; DPPH free radical scavenging activity; prenylated phenolic compound; labdane-type diterpene
AbstractPropolis is a resinous hive product collected by honeybees from various plant sources. It is extensively used in food, beverage and in folk medicine for treating various ailments and reported to have broad spectrum of biological activities. The hepatoprotective activity of propolis and constituents from its MeOH extract belonging to various classes were tested on D-galactosamine (d-GalN)/tumor necrosis factor-α (TNF-α)-induced cell death in primary cultured mouse hepatocytes. The result indicated that hepatoprotective activity of alcoholic extract of tropical Brazilian propolis is mainly due to phenolic compounds including flavonoids. All the four isolated flavonoids possessed stronger inhibitory activity (IC50, less than 25 μM) than silibinin (IC50, 39.6 μM) on TNF-α-induced cell death. The labdane-type diterpenes isolated from the MeOH extract also exhibited significant hepatoprotective activity in the same experimental model. Moreover, the labdane-type diterpenes and some of the prenylated phenolic compounds possessed antibacterial activity against Helicobacter pylori.
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LanguageEnglish
Peer reviewedYes
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NPARC number21274816
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Record identifier47c51756-e15e-418b-b1b3-ba168026eedc
Record created2015-04-14
Record modified2016-05-09
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