Rapid analysis of liquid formulations containing sodium chloride using laser-induced breakdown spectroscopy

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DOIResolve DOI: http://doi.org/10.1016/j.jpba.2004.06.004
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TypeArticle
Journal titleJournal of Pharmaceutical and Biomedical Analysis
Volume36
Issue2
Pages277284; # of pages: 8
SubjectLaser-induced breakdown spectroscopy (LIBS); Sodium chloride; Isotonic solution; Liquid formulation; Process analytical technologies (PAT)
AbstractThe purpose of this work was to demonstrate the possibilities offered by laser-induced breakdown spectroscopy (LIBS) for the direct and rapid analysis of pharmaceutical liquid formulations. Sodium chloride in solution was chosen as a model compound. A pulsed Nd:YAG laser (1064 nm) was used to produce a gaseous plasma from the liquid sample. The ensuing plasma emission was spectrally analysed, and the intensity of an atomic line from sodium was used to quantitate the sodium chloride. Using surface analysis of a flowing solution, the precision (percent R.S.D.) of a measurement lasting 50 s (average of 50 laser shots at 1 shot/s) was approximately 0.5 percent for isotonic solutions. On a non-flowing solution, a 50 s measurement had an R.S.D. of 1.8 percent. Direct analysis in closed (transparent) bottles was possible but more complex, requiring the superimposition of two sequential laser sparks. Using a surface procedure, common commercial isotonic products (including injectable, bacteriostatic injectable, and nasal solutions) were analysed. Their sodium content (corresponding to 0.9 percent sodium chloride) was accurately determined in all cases, demonstrating the capabilities of LIBS for the rapid analysis of liquid pharmaceutical products.
Publication date
PublisherElsevier
LanguageEnglish
AffiliationNRC Industrial Materials Institute; National Research Council Canada
Peer reviewedYes
NRC number46810
NPARC number18937299
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Record identifier48af8624-f84d-45f5-936a-e943828f0dca
Record created2011-11-25
Record modified2016-05-09
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