Infrared spectroscopic characterisation of multiple sclerosis plaques in the human central nervous system

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DOIResolve DOI: http://doi.org/10.1016/0925-4439(93)90078-F
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TypeArticle
Journal titleBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
ISSN0925-4439
Volume1182
Issue3
Pages333337; # of pages: 5
SubjectInfrared spectroscopy; Multiple sclerosis; Multiple sclerosis plaque; Central nervous system; (Human)
AbstractFourier transform infrared spectroscopy has been used for the characterisation of white matter, grey matter and multiple sclerosis plaques from human central nervous system tissue. We demonstrate significant differences in the infrared spectra of the three types of tissue, which show that an infrared spectroscopic discrimination of multiple sclerosis plaques from healthy brain tissue is possible in principle. The spectral changes reveal pronounced lipid loss in plaques, consistent with the demyelinating nature of the disease. The chronic plaques studied here can also be distinguished from other non-myelinated areas of the brain, based on difference in water content.
Publication date
PublisherElsevier Science Publishers B.V.
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Biodiagnostics
Peer reviewedYes
NRC number4
34726
NPARC number9742413
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Record identifier48e0f789-8b33-4715-9591-5aa654bc02fe
Record created2009-07-17
Record modified2016-12-09
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