BigBrain: An ultrahigh-resolution 3D human brain model

Download
  1. Get@NRC: BigBrain: An ultrahigh-resolution 3D human brain model (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1126/science.1235381
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleScience
ISSN0036-8075
Volume340
Issue6139
Pages14721475; # of pages: 4
Subjectbrain; histology; hominid; hypothesis testing; numerical model; article; brain; brain mapping; brain region; human; human tissue; model; neuroanatomy; primary motor cortex; priority journal; simulation; tissue section; ultrahigh resolution three dimensional model; Aged; Brain; Brain Mapping; Cerebral Cortex; Female; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Microtomy
AbstractReference brains are indispensable tools in human brain mapping, enabling integration of multimodal data into an anatomically realistic standard space. Available reference brains, however, are restricted to the macroscopic scale and do not provide information on the functionally important microscopic dimension. We created an ultrahigh-resolution three-dimensional (3D) model of a human brain at nearly cellular resolution of 20 micrometers, based on the reconstruction of 7404 histological sections. "BigBrain" is a free, publicly available tool that provides considerable neuroanatomical insight into the human brain, thereby allowing the extraction of microscopic data for modeling and simulation. BigBrain enables testing of hypotheses on optimal path lengths between interconnected cortical regions or on spatial organization of genetic patterning, redefining the traditional neuroanatomy maps such as those of Brodmann and von Economo.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21270714
Export citationExport as RIS
Report a correctionReport a correction
Record identifier4a8c62e3-6d03-4044-b981-639e0d2a527b
Record created2014-02-17
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)