A cultivated form of a red seaweed (Chondrus crispus), suppresses β-amyloid-induced paralysis in Caenorhabditis elegans

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DOIResolve DOI: http://doi.org/10.3390/md13106407
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TypeArticle
Journal titleMarine Drugs
ISSN1660-3397
Volume13
Issue10
Pages64076424; # of pages: 18
Subjectβ-amyloid; Caenorhabditis elegans; cultivated Chondrus crispus; glycolipid; monogalactosyl diacylglycerol (MGDG); neuroprotection; red seaweeds
AbstractWe report here the protective effects of a methanol extract from a cultivated strain of the red seaweed, Chondrus crispus, against β-amyloid-induced toxicity, in a transgenic Caenorhabditis elegans, expressing human Aβ1-42 gene. The methanol extract of C. crispus (CCE), delayed β-amyloid-induced paralysis, whereas the water extract (CCW) was not effective. The CCE treatment did not affect the transcript abundance of amy1; however, Western blot analysis revealed a significant decrease of Aβ species, as compared to untreated worms. The transcript abundance of stress response genes; sod3, hsp16.2 and skn1 increased in CCE-treated worms. Bioassay guided fractionation of the CCE yielded a fraction enriched in monogalactosyl diacylglycerols (MGDG) that significantly delayed the onset of β-amyloid-induced paralysis. Taken together, these results suggested that the cultivated strain of C. crispus, whilst providing dietary nutritional value, may also have significant protective effects against β-amyloid-induced toxicity in C. elegans, partly through reduced β-amyloid species, up-regulation of stress induced genes and reduced accumulation of reactive oxygen species (ROS).
Publication date
LanguageEnglish
AffiliationAquatic and Crop Resource Development; National Research Council Canada
Peer reviewedYes
NPARC number21277129
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Record identifier4b80ed6a-222a-46fb-824a-f727ed4891fc
Record created2015-12-10
Record modified2016-05-09
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