Hepatitis C virus and microRNAs: MiRed in a host of possibilities

  1. Get@NRC: Hepatitis C virus and microRNAs: MiRed in a host of possibilities (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1016/j.coviro.2014.03.004
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Journal titleCurrent Opinion in Virology
Pages110; # of pages: 10
SubjectmicroRNA; biogenesis; disease association; disease course; hepatitis C; Hepatitis C virus; host pathogen interaction; life cycle; liver cell carcinoma; liver fibrosis; pathogenesis; regulatory mechanism; steatosis; virus genome; virus immunity
AbstractIt is well-established that the host microRNA (miRNA) milieu has a significant influence on the etiology of disease. In the context of viruses, such as hepatitis C virus (HCV), microRNAs have been shown to influence viral life cycles both directly, through interactions with the viral genome, and indirectly, through regulation of critical virus-associated host pathways. Several miRNA profiling studies have demonstrated that HCV infection aberrantly regulates a significant number of human miRNA. However, the biological relevance of these modulations remains poorly understood. In this review, we summarize recent research that has shed light on the pro-viral and anti-viral roles of HCV-induced changes in human miRNA expression and their significance in the development of HCV related sequelae and response to therapy.
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AffiliationNational Research Council Canada; Medical Devices
Peer reviewedYes
NPARC number21272668
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Record identifier4b9379a7-c00e-4e97-95ee-2fb4f0a0e8aa
Record created2014-12-03
Record modified2016-05-09
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