A new vitamin E analogue more active than α-tocopherol in the rat curative myopathy bioassay

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DOIResolve DOI: http://doi.org/10.1016/0014-5793(86)80877-8
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TypeArticle
Journal titleFEBS Letters
ISSN0014-5793
Volume205
Issue1
Pages117120; # of pages: 4
Subject3,4 dihydro 5 hydroxy 2,4,6,7 tetramethyl 2 (4,8,12 trimethyltridecyl)benzofuran acetate; alpha tocopherol; pyruvate kinase; unclassified drug; animal experiment; article; biological model; blood and hemopoietic system; drug comparison; drug screening; drug synthesis; muscle; muscle disease; nonhuman; oral drug administration; priority journal; rat; Animals; Diet; Kinetics; Male; Muscles; Pyruvate Kinase; Rats; Rats, Inbred Strains; Stereoisomerism; Vitamin E; Vitamin E Deficiency; Animalia
AbstractVitamin E owes its biological effects to its antioxidant activity. Kinetic and mechanistic studies on phenolic antioxidants in vitro have led us to design and synthesize all-rac-2,4,6,7-tetramethyl-2-(4',8',12'-trimethyltridecyl)-5-hydroxy-3,4-dihydrobenzofuran, 3. In the rat curative myopathy bioassay the acetate of this compound has 1.5-1.9 times the bioactivity of all-rac-α-tocopherol acetate. This represents the first time that a rationally designed synthetic 'vitamin' has been found to have more activity in vivo than the corresponding natural vitamin. © 1986.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21276632
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Record identifier4bd2bb40-bfa9-495b-addd-74508add7b3d
Record created2015-10-13
Record modified2016-05-09
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