Functional brain mapping at 9.4T using a new MRI-compatible electrode chronically implanted in rats

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DOIResolve DOI: http://doi.org/10.1002/mrm.21803
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TypeArticle
Journal titleMagnetic Resonance in Medicine
Volume61
Issue1
Pages222228; # of pages: 7
SubjectMRI; fMRI; epilepsy; electrode
AbstractThere is a need for acute and chronic stimulation of the brain within the MRI for studies of epilepsy, as well as of deep brain stimulation for movement and behavioral disorders. This paper describes the production and characteristics of carbon fiber based electrodes for acute and chronic stimulation in the brain. Increasing MRI field strengths are making it increasingly difficult to introduce foreign objects without a susceptibility artifact. This paper describes the production of, and the characteristics of carbon fiber based electrodes. These are biocompatible and can be implanted for chronic studies. We show the use of these electrodes at 9.4T for studying functional activation. Data are presented showing regional connectivity. Activation not only occurs near the electrode, but at sites distant and often contralateral to the electrode. In addition, there were sites showing strong negative activation to stimulation both with direct stimulation and during a kindling associated seizure.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NPARC number19734710
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Record identifier4c78b48e-cc59-4b30-acbb-c7b4d7588066
Record created2012-04-05
Record modified2016-05-09
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