Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium

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DOIResolve DOI: http://doi.org/10.1016/j.exppara.2010.02.009
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TypeArticle
Journal titleExperimental Parasitology
Volume125
Issue4
Pages315324; # of pages: 10
Subjectactivity; analysis; Anti-parasitic; Apicomplexa; bio; Biotechnology; blood; Brain; Candida; Candida albicans; Cells; Central Nervous System; Cysteamine; Cysteine; deficiency; Endocytosis; Epithelial Cells; Genes; genetics; genome; Human; I; immunology; In Vitro; Inflammation; Interleukin-12; metabolism; methods; Mice; microbiology; Mouse model; Mutation; pathology; pharmacokinetics; pharmacology; Phospholipids; Plasmodium; Pressure; Protease; Protein; Stress; synthesis; therapy; Vitro
AbstractIn mice, loss of pantetheinase activity causes susceptibility to infection with Plasmodium chabaudi AS. Treatment of mice with the pantetheinase metabolite cysteamine reduces blood-stage replication of P. chabaudi and significantly increases survival. Similarly, a short exposure of Plasmodium to cysteamine ex vivo is sufficient to suppress parasite infectivity in vivo. This effect of cysteamine is specific and not observed with a related thiol (dimercaptosuccinic acid) or with the pantethine precursor of cysteamine. Also, cysteamine does not protect against infection with the parasite Trypanosoma cruzi or the fungal pathogen Candida albicans, suggesting cysteamine acts directly against the parasite and does not modulate host inflammatory response. Cysteamine exposure also blocks replication of P. falciparum in vitro; moreover, these treated parasites show higher levels of intact hemoglobin. This study highlights the in vivo action of cysteamine against Plasmodium and provides further evidence for the involvement of pantetheinase in host response to this infection. -¬ 2010 Elsevier Inc
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Biotechnology Research Institute
Peer reviewedYes
NRC number52759
NPARC number16225331
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Record identifier4c8f59b8-8419-4563-98c6-e0f0f9723350
Record created2010-11-05
Record modified2016-05-09
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