Diffusion abnormality maps in demyelinating disease: correlations with clinical scores

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DOIResolve DOI: http://doi.org/10.1016/j.ejrad.2011.12.014
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TypeArticle
Journal titleEuropean Journal of Radiology
ISSN0720-048X
Volume81
Issue3
Pagese386e391
SubjectDiffusion tensor imaging; TBSS; Multiple sclerosis
AbstractBackground and purpose - Magnetic resonance imaging (MRI) has been explored as a noninvasive tool to assess pathology in multiple sclerosis (MS) patients. However, the correlation between classical MRI measures and physical disability is modest in MS. The diffusion tensor imaging (DTI) MRI technique holds particular promise in this regard. The present study shows brain regions where FA and individual diffusivities abnormalities are present and check their correlations with physical disability clinical scores. Methods - Eight patients and 12 matched healthy controls were recruited. The Multiple Sclerosis Functional Composite was administered. For MR-DTI acquisitions, a Genesis Signa 1.5T MR system, an EP/SE scanning sequence, 25 gradient directions were used. Results - Tract Based Spatial Statistics (TBSS) group comparisons showed reduced FA and increased individual diffusivities in several brain regions in patients. Significant correlations were found between FA and: EDSS, 9-HPT(NON)DOM and 25FW score; between λ2 and: P100 (r&l), 9-HPT(NON)DOM and 25FW; between λ3 and: 9-HPT(NON)DOM and 25FW score. Conclusions - Fractional anisotropy and individual radial diffusivities proved to be important markers of motor disabilities in MS patients when the disease duration mean and the disability scores values range are relatively high.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
IdentifierS0720048X11008655
NPARC number21268727
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Record identifier4d46ed0c-2c64-4bbf-a6f5-c47e6187fe94
Record created2013-11-08
Record modified2016-05-09
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